Mechanisms of spasmolytic action of bile salts in depolarized guinea-pig taenia coli.
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Inhibitory mechanisms of isoprenaline in the guinea-pig taenia coli.
The beta-receptor stimulating effect of isoprenaline on the spontaneous activities of the guinea-pig taenia coli was investigated in the presence of an alpha-receptor blocking agent, phentolamine (2 X 10(-6) M). Substitution of the external Naion with Li, choline, tris-hydroxymethyl aminomethane or Kion greatly reduced the inhibitory effect of isoprenaline. A treatment with ouabain (4 X 10(-6) ...
متن کاملMechanisms of inhibitory action of phenylephrine in guinea-pig taenia coli.
The effect of phenylephrine, an alpha-agonist, on the Ca movements and the influence of removal of external Na+ on the relaxant activity of phenylephrine were examined in the taenia coli of guinea pigs. Phenylephrine (10(-7)-10(-5)M) caused dose-dependent relaxation of the taenia coli contracted by 20 mM KCl in Locke-Ringer solution. Phenylephrine (10(-5) M) suppressed the spike discharges of t...
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NAGASAWA, J. and Suzuxi, T. Ca Flux and Action Potential in Smooth Muscle of Guinea-pig Taenia Coli. Tohoku J. exp. Med., 1970, 102(1), 1-12. •\ Ca uptake and efflux in the smooth muscle cell of guinea-pig taenia coli were estimated in the normal Krebs solution and in Krebs solution containing MnCl2. MnCl2 had no significant effect on the efflux of 45Ca in the concentration range between 1.0mM ...
متن کاملMechanism of relaxant action of papaverine. Effect on caffeine-induced contraction of guinea pig taenia coli.
The mode of action of papaverine on smooth muscle relaxation was examined through analyzing its effects on caffeine-induced contraction of guinea pig taenia coli, which might be due to calcium ion mobilized from intracellular store sites. Caffeine contraction induced in normal solution at 32 degrees C was decreased in the presence of papaverine but increased after the removal of papaverine, and...
متن کاملCalcium and the contractile effect of carbachol in the depolarized guinea-pig taenia caecum.
Carbachol (10-8-10-3 M) caused a phasic contraction in the guinea-pig taenia caecum suspended in the Ca-free, K-Tyrode solution. The action of carba chol was concentration-related and was completely antagonized by atropine (10-6 g/ml). The capacity to contract in the absence of external Ca was removed by short term exposure to a high concentration of carbachol (...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1986
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.9.473